日本医科大学 病理学講座　統御機構・腫瘍学　Integrative Oncological Pathology

Matsuda Y, Hagio M, Yanagisawa Y, Suzuki T, Naito Z, Ishiwata T：Nestin regulates stem cell functions of pancreatic cancer cells.

Sato A, Ishiwata T, Yamamoto T, Matsuda Y, Asakura H, Takeshita T, Naito Z : Role of stem cell marker, nestin in human uterine intraepithelial neoplasia and cervical cancer.

Hagio M, Matsuda Y, Kawamoto Y, Ishiwata T : Comparison of tumor-forming ability in different fractions of pancreatic ductal adenocarcinoma cells.

Kure S, Matsuda Y, Hagio M, Suzuki T, Ueda J, Yamahatsu K, Yamamoto T, Ishiwata T, Naito Z : Expression of Cancer Stem Cell Markers in Pancreatic Ductal Adenocarcinomas and Pancreatic Intraepithelial Neoplasias

Akiyama M, Matsuda Y, Hagio M, Kawahara K, Suzuki T, Ishiwata T, Kawana S, Naito Z : The stem cell marker nestin inhibits growth and invasion of malignant melanoma.

Takayama R, Ishiwata T, Ansai S, Yamamoto T, Matsuda Y, Kawana S, Naito Z : Lumican as a novel differential diagnostic maker for Bowen's disease and actinic keratosis

Ueda J, Matsuda Y, Yamahatsu K, Uchida E, Naito Z, Ishiwata T : Epithelial Splicing Regulatory Protein 1 Modulates Cell Growth, Migration, and Invasion of Human Pancreatic Ductal Adenocarcinoma

Kudo M, Saito A, Nagasaki M, Miyano S, Naito Z : Modeling and Simulation Analysis of Insulin Secretory Functions of β-cells.

Matsuda Y, Yamahatsu K, Ueda J, Kawahara K, Akiyama M, Hagio M, Naito Z, Ishiwata T: Human pancreatic cancer cell line derived from metastatic tumor in NOG mice possesses high-stemness ability.

Ueda J, Matsuda Y, Yamahatsu K, Uchida E, Naito Z, Ishiwata T: Expression and roles of epithelial splicing regulatory protein 1 in human pancreatic cancer.

Hagio M, Matsuda Y, Suzuki T, Naito Z, Ishiwata T: Nestin modulates EMT molecules and transcription factors in human pancreatic cancer cells.

Yamahatsu K, Matsuda Y, Hagio M, Aimoto T, Nakamura K, Uchida E, Naito Z. Nestin inhibits proliferation of vascular endothelial cells in vitro and tumor angiogenesis in pancreatic cancer in vivo.

Toshiyuki Ishiwata, Yoko Matsuda, Masahito Hagio, Kazuya Yamahatsu, Tetsushi Yamamoto, Zenya Naito : Cancer stem cell markers in precancerous lesion and pancreatic cancer.

• Zenya Naito, Yoko Matsuda, Wei-Xia Peng, Kazuya Yamahatsu, Junji Ueda, Yoko Kawamoto, Kiyoshi Teduka, Tomoko Seya, Yoshiharu Ohaki, Toshiyuki Ishiwata : Fibroblast growth factor receptor 2 as a novel therapeutic target for colorectal cancer cell growth.




• Toshiyuki Ishiwata,Yoko Matsuda, Kiyoko Kawahara, Tetsushi Yamomoto, Kiyoshi Teduka, Taeko Suzuki, Wei-Xia Peng, Murray Korc, Zenya Naito: Fibroblast growth factor receptor 2 as a novel therapeutic target for cancer cell growth and angiogenesis in human pancreatic cancer.




• Yoko Matsuda, Kazuya Yamahatsu, Kiyoko Kawahara, Taeko Suzuki, Takenori Fujii, Tetsushi Yamamoto, Murray Korc, Zenya Naito, Toshiyuki Ishiwata : Nestin regulates pancreatic cancer stem cell functions.




• Kazuya Yamahatsu, Yoko Matsuda, Tetsushi Yamamoto, Takayuki Aimoto, Yoshiharu Nakamura, Makoto Hiroi, Eiji Uchida, Zenya Naito, Toshiyuki Ishiwata : Nestin as a novel angiogenic marker and target for anti-angiogenic therapy in human pancreatic cancer.




• Michiko Akiyama, Kiyoko Kawahara, Yoko Matsuda, Taeko Suzuki, Tetsushi Yamamoto, Toshiyuki Ishiwata, Zenya Naito : The stem cell marker nestin is a novel therapeutic target to suppress tomor growth and invasion of malignant melanoma.




• Junji Ueda, Kiyoko Kawahara, Takenori Fujii, Kazuya Yamahatsu, Taeko Suzuki, Yoko Matsuda, Eiji Uchida, Murray Korc, Zenya Naito, Toshiyuki Ishiwata : Establishment of novel human pancreatic cancer cell lines from liver and lung metastases in NOD/SCID/yc (NOG) mice.

• Yamahatsu K, Matsuda Y, Ishiwata T, Yamamoto T, Fujii T, Aimoto T, Nakamura Y, Hiroi M, Uchida E, Naito Z : Characterization of Nestin-positive blood vessels in human pancreatic cancer.




• Fujii T, Matsuda Y, Yamahatsu K, Akiyama H, Teduka K, Yamamoto T, Ishiwata T, Uchida E and Naito Z : A metastatic model of pancreatic cancer using NOD/Shi-scid, IL-2Rγnull(NOG) mice.




• Kawamoto Y, Matsuda Y, Ishiwata T, Yamamoto T, Suzuki T, Kawahara K, Naito Z : Expression patterns of cytoskeletal proteins in human pancreatic cancer cells in a novel three-dimensional spheroidal culture.

Title: Novel therapeutic targets for cancer

• Toshiyuki Ishiwata: FGFR 2IIIc isoforms as a novel therapeutic target of cancer cell growth.




• Tetsushi Yamamoto: Roles of lumican in pancreatic cancer : Aiming at developing new anti-cancer drugs.


• Yoko Matsuda: Correlation of the stem cell marker Nestin with migration and invasion of pancreatic cancer

• Toshiyuki Ishiwata, Yoko Matsuda, Kiyoko Kawahara, Tetsushi Yamamoto, Kiyoshi Teduka, Eiji Uchida, Murray Korc, Zenya Naito: Fibroblast growth factor receptor (FGFR) 2 IIIc, is a novel molecular target for suppressing pancreatic cancer cell growth and migration.




• Yoko Matsuda, Toshiyuki Ishiwata, Masao Kawamoto, Tetsushi Yamomoto, Kiyoko Kawahara, Kiyoshi Teduka, Wei-Xia Peng, Kazuya Yamahatsu, Murray Korc, Zenya Naito: Stem cell marker Nestin regulated the migration and invasion of pancreatic cancer cells.




• Tetsushi Yamamoto, Toshiyuki Ishiwata, Yoko Matsuda, Munehiko Onda, Kazuya Yamahatsu, Kiyoko Kawahara, Yoko Kawamoto, Eiji Uchida, Zenya Naito:Lumican as a new target to develop molecularly-targeted drugs for pancreatic cancer.




• Rieko Kawase, Toshiyuki Ishiwata, Yoko Matsuda, Munehiko Onda, Kiyoshi Teduka, Kiyoko Kawahara, Toshiyuki Takeshita, Zenya Naito: Expression and role of fibroblast growth factor receptor2 IIIc in human uterine cervical intraepithelial neoplasia (CIN) and invasive cervical cancer.




• Zenya Naito, Yoko Matsuda, Yoko Kawamoto, Takenori Fujii, Taeko Suzuki, Munehiko Onda, Tetsushi Yamamoto, Tomoko Seya, Yoshiharu Ohaki, Toshiyuki Ishiwata: Fibroblast growth factor receptor 2IIIc enhances the growth of colorectal adenocarcinoma cells.

Ishiwata T, Matsuda Y, Yamamoto T, Uchida E, Korc M, Naito Z: Expression and roles of FGFR2 isoforms in pancreatic cancer cells.

• Yamamoto T, Ishiwata T, Motoda N, Kawahara K, Fujii T, Matsuda Y, Onda M, Naito Z: Signal transduction pathway analysis to induce cell growth and vascular endothelial growth factor-A release by keratinocyte growth factor in pancreatic cancer cells.
　　　　
• Kudo M, Fujii T, Teduka K, Kawamoto Y, Suzuki T, Kawahara K, Ishiwata t, Naito Z: Efficient secretion of insulin from beta-cells requires cell-to-cell adhesion.